Human Growth hormone replaced pituitaryderived human Human Growth hormone, also referred to as recombinant human Human Growth are localized in the ion of chromosome 17 and are closely related to human chorionic somatomammotropin hCS, and prolactin PRL are a group of homologous hormones with Human Growthpromoting and lactogenic activity.The major isoform of the human HGH moleculeThe genes for human Human Growth hormone on the tissues of the body can generally be described as anabolic building up. Like most other protein hormones HGH acts by interacting with a specific receptor on the surface of cells.Height Human Growth in childhood is the best known effect of HGH action, and appears to be stimulated by at least two mechanisms. 1. HGH directly stimulates division and multiplication of chondrocytes of cartilage. These are the primary cells in the growing ends epiphyses of childrens long bones arms, legs, digits. 2. HGH also stimulates production of insulinlike Human Growth factor 1 IGF1, formerly known as somatomedin C, a hormone homologous to proinsulin.The liver is a major target organ of HGH for this process, and is the principal site of IGF1 production. IGF1 has Human Growthstimulating effects on a wide variety of tissues. Additional IGF1 is generated within target tissues, making it apparently both an endocrine and an autocrineparacrine hormone.Although height Human Growth is the best known effect of HGH action, and appears to be stimulated by at least two provocative stimuliIncreased IGF1 levels after a few months of HGH treatmentSevere HGH deficiency in childhoodWhen treated with HGH, a severely deficient child will begin to grow faster within months.In the first year of treatment, the rate of growth may increase from half as fast as other children are growing to twice as fast e.g., from 1 inch a year to 4 inches, or
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