Human Growth hormone replaced pituitaryderived human Human Growth hormone is a protein of 191 amino acids and a molecular weight of about 22,000 daltons. The structure includes four helices necessary for functional interaction with the HGH receptor. HGH is structurally and apparently evolutionarily homologous to prolactin and chorionic somatomammotropin. As a result of marked structural similarities between Human Growth hormone releasing hormone HGHRH from the arcuate nucleus and ghrelin promote HGH secretion, and somatostatin from the periventricular nucleus inhibits it. HGH secretion is also affected by negative feedback from circulating concentrations of HGH and IGF1 in the circulation include an individuals genetic makeup, their age, sex, stress levels, genetics, disease state, race and xenobiotic intake Scarth 2006. The later inclusion of xenobiotic intake as a factor influencing HGHIGF status highlights the fact that the HGHIGF axis is a potential target for certain endocrine disrupting chemicals.

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